You Won’t Believe the Shocking Drama Unfolding Between Yang, Schmitt, and More!

Grey’s Anatomy has had to say goodbye to many a main character after running for 22 seasons.

From tragic deaths of beloved doctors to shocking departures of actors and actresses welcomed into the fold of Seattle Grace Mercy West Hospital, later renamed Grey Sloan Memorial Hospital, in the Shonda Rhimes-created medical drama series.

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Find the actors and actresses who have left the show and what characters they played below:

Sandra Oh portrayed Dr. Cristina Yang from 2005 to 2022 on the medical series.

Patrick Dempsey played Dr. Derek Shepherd on Grey’s Anatomy from 2005 to 2022.

T.R. Knight played Dr. George O’Malley from 2005-2022.