You won’t believe what Shonda Rhimes and Ellen Pompeo are planning for the new Grey’s Anatomy spinoff!

 

The untitled drama, executive produced by Ellen Pompeo, marks the fourth series in the ‘Grey’s’ franchise and will follow doctors at a rural West Texas medical center

ABC is officially expanding the Grey’s Anatomy universe with a brand-new spinoff series from creator and executive producer Shonda Rhimes and current Grey’s showrunner and executive producer Meg Marinis.

More than 20 years after the hit medical drama first premiered, this new untitled medical drama has received a straight-to-series order for the 2026-2027 season. Longtime Grey’s star Ellen Pompeo is also attached as an executive producer. According to Deadline, the series is expected to premiere in midseason 2027.

ABC and the official Grey’s Anatomy Instagram account confirmed the news in a joint social media announcement alongside the caption, “Just what the doctor ordered. 🩺🤠.”

The new series marks the fourth installment in the Grey’s Anatomy franchise following the flagship series, Private Practice and Station 19. It will also be the franchise’s first series not set on the West Coast or in a major metropolitan city.

Per Deadline, the drama is described as an “edgy” series centered on a team working at a rural West Texas medical center that serves as “the last chance for care before miles of nowhere.”

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Unlike previous spinoffs, the new series will not reportedly revolve around an established Grey’s Anatomy character. Kate Walsh led Private Practice as Addison Montgomery, while Jason George headlined Station 19 as Ben Warren.

“I am incredibly excited to expand the Grey’s Anatomy universe,” Marinis said in a statement to Deadline. “This opportunity will bring new characters and stories to life that will embody the same heart, emotion and connection audiences have loved from Grey’s for more than two decades — all set in my home state of Texas. I am so grateful to Shonda Rhimes for creating this dynamic world and feel so fortunate that I get to be a part of it.”

Grey’s Anatomy first premiered on ABC in 2005 and made television history in 2019 when it surpassed ER as the longest-running primetime medical drama in the United States. The series has since crossed the 450-episode mark.

At the time of the milestone, Pompeo reflected on the longevity of the hit series and its impact on her life and career.

“Obviously I never anticipated the show still being the no. 1 show on the network,” Pompeo previously told PEOPLE. “How do you walk away from a hit? The fans will dictate when the show ends. As much as we think we’re in control, we’re not. It’s the fans’ show at this point. They control how long the show goes. We’ll see. I kind of just take it year by year and see.”

“I think the biggest lesson is what something can be if you give it the chance to turn it around,” she added. “We had so much drama in the early days. The show was so strong and so solid and so amazing, then we had all these behind-the-scenes drama and then it would’ve been really easy to walk away and say, ‘I don’t want to deal with that anymore.’”

Since stepping back as a full-time series regular in season 19, Pompeo has expanded her acting portfolio. This includes starring and executive producing the limited drama miniseries Good American Family, which debuted in March 2025 on Hulu.